SDUY816
SDUY816 is an oral active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. SDUY816 exhibits analgesic effects and demonstrates good safety and pharmacokinetic profiles, with an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral administration, 10 mg/kg) . SDUY816 has potential applications in the research of neuropathic pain disorders[1].
Product Specifications
UNSPSC
12352005
Target
Aminopeptidase; Neprilysin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Smiles
O=C(N[C@H](CC1=CNC2=C1C=CC=C2)C(NO)=O)C3=CC=C(I)C=C3
Molecular Formula
C18H16IN3O3
Molecular Weight
449.24
References & Citations
[1]Zhang N, et al. Synthesis and biological evaluation of new dual APN/NEP inhibitors as potent analgesics. Bioorg Chem. 2025 Mar;156:108210.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
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