NYY-6a
NYY-6a is a Ferroptosis inhibitor. NYY-6a shows significant inhibitory activity against RSL3-induced ferroptosis across 786-O and HT-1080 cells with EC50s of 52 and 50 nM, respectively. NYY-6a functions as a radical trapping antioxidant (RTA) with efficacy of diminishing lipid peroxidation comparable to ferrostatin-1 and liproxtatin-1. NYY-6a is potential for ferroptosis related pathologies reasearch[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis
Related Pathways
Apoptosis
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Smiles
CC1(C2=CC=CC=C2)NC3=CC=C(NC(OCC4=CC=CC=C4)=O)C=C3OC1
Molecular Formula
C23H22N2O3
Molecular Weight
374.43
References & Citations
[1]Wan BW, et al. Discovery of novel benzo[b][1,4]oxazine derivatives as ferroptosis inhibitors. Bioorg Chem. 2025 Mar;156:108201. doi: 10.1016/j.bioorg.2025.108201. Epub 2025 Jan 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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