NYY-6a

NYY-6a is a Ferroptosis inhibitor. NYY-6a shows significant inhibitory activity against RSL3-induced ferroptosis across 786-O and HT-1080 cells with EC50s of 52 and 50 nM, respectively. NYY-6a functions as a radical trapping antioxidant (RTA) with efficacy of diminishing lipid peroxidation comparable to ferrostatin-1 and liproxtatin-1. NYY-6a is potential for ferroptosis related pathologies reasearch[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis

Related Pathways

Apoptosis

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Smiles

CC1(C2=CC=CC=C2)NC3=CC=C(NC(OCC4=CC=CC=C4)=O)C=C3OC1

Molecular Formula

C23H22N2O3

Molecular Weight

374.43

References & Citations

[1]Wan BW, et al. Discovery of novel benzo[b][1,4]oxazine derivatives as ferroptosis inhibitors. Bioorg Chem. 2025 Mar;156:108201. doi: 10.1016/j.bioorg.2025.108201. Epub 2025 Jan 23.