5-LOX/NO-IN-1

5-LOX/NO-IN-1 (Compound 7e) is a 5-LOX and NO release inhibitor. 5-LOX/NO-IN-1 shows an IC50 of 2.833 μM for 5-LOX. 5-LOX/NO-IN-1 has anti-inflammatory effects[1].

Product Specifications

UNSPSC

12352005

Target

Lipoxygenase; NO Synthase

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=C1N(CC2=NC(C3=CC=C(OC)C(OC)=C3)=NO2)C=NC4=C1C=NN4C5=CC=CC=C5

Molecular Formula

C22H18N6O4

Molecular Weight

430.42

References & Citations

[1]Aziz MA, et al. Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies. Bioorg Chem. 2025 Mar;156:108181.