5-LOX/NO-IN-1
5-LOX/NO-IN-1 (Compound 7e) is a 5-LOX and NO release inhibitor. 5-LOX/NO-IN-1 shows an IC50 of 2.833 μM for 5-LOX. 5-LOX/NO-IN-1 has anti-inflammatory effects[1].
Product Specifications
UNSPSC
12352005
Target
Lipoxygenase; NO Synthase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C1N(CC2=NC(C3=CC=C(OC)C(OC)=C3)=NO2)C=NC4=C1C=NN4C5=CC=CC=C5
Molecular Formula
C22H18N6O4
Molecular Weight
430.42
References & Citations
[1]Aziz MA, et al. Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies. Bioorg Chem. 2025 Mar;156:108181.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-170957/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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