C-Met/Axl-IN-1

C-Met/Axl-IN-1 (Compound 22a) is an orally active and selective type II c-Met/Axl inhibitor with IC50 values of 1 nM and 10 nM, respectively. C-Met/Axl-IN-1 can inhibit proliferation, induce cell cycle arrest and apoptosis of tumor cells. C-Met/Axl-IN-1 has strong anti-tumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; c-Met/HGFR; TAM Receptor

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

FC1=C(C=CC(NC(C2=CC=C(C)N(C3=CC=C(F)C=C3)C2=O)=O)=C1)C4=CNC5=NC=NC(N)=C54

Molecular Formula

C25H18F2N6O2

Molecular Weight

472.45

References & Citations

[1]Qin S, et al. Identification of a 7H-pyrrolo[2,3-d]pyrimidin derivatives as selective type II c-Met/Axl inhibitors with potent antitumor efficacy. Bioorg Chem. 2025 Mar;156:108187.