C-Met/Axl-IN-1
C-Met/Axl-IN-1 (Compound 22a) is an orally active and selective type II c-Met/Axl inhibitor with IC50 values of 1 nM and 10 nM, respectively. C-Met/Axl-IN-1 can inhibit proliferation, induce cell cycle arrest and apoptosis of tumor cells. C-Met/Axl-IN-1 has strong anti-tumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR; TAM Receptor
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
FC1=C(C=CC(NC(C2=CC=C(C)N(C3=CC=C(F)C=C3)C2=O)=O)=C1)C4=CNC5=NC=NC(N)=C54
Molecular Formula
C25H18F2N6O2
Molecular Weight
472.45
References & Citations
[1]Qin S, et al. Identification of a 7H-pyrrolo[2,3-d]pyrimidin derivatives as selective type II c-Met/Axl inhibitors with potent antitumor efficacy. Bioorg Chem. 2025 Mar;156:108187.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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