QXG-6442

QXG-6442 is a CK1α Molecular Glue Degrader. QXG-6442 exhibits CK1α degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. QXG-6442 induces antiproliferative effects in MOLM-14 cell line[1].

Product Specifications

CAS Number

[3099928-67-0]

UNSPSC

12352005

Target

Casein Kinase; Molecular Glues

Related Pathways

Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.32

Smiles

O=C(C1=CN2C=CC=CC2=N1)NC3=CC4=C(C(N(C4)C5CCC(NC5=O)=O)=O)C=C3

Molecular Formula

C21H17N5O4

Molecular Weight

403.39

References & Citations

[1]Geng Q, et al. Development of Potent and Selective CK1α Molecular Glue Degraders. J Med Chem. 2025 Feb 13;68 (3) :3180-3196.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CK1

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MG219346 10 µg

Aff1 (NM_133919) Mouse Tagged ORF Clone

Ask

View Details

NBP3-20168AF700 0.1 mL

Rabbit Polyclonal ADP-ribosylarginine hydrolase Antibody [Alexa Fluor 700]

Ask

View Details

MF-0074440-01 50 µL

Anti-FGFR4 Antibody (7B625)

Ask

View Details

MF-0074440-02 100 µL

Anti-FGFR4 Antibody (7B625)

Ask

View Details

ADC-L-014 Each

Fmoc-Gly3-Val-Cit-PAB

Ask

View Details

STJ16101167 1 mL

Anti-Collagen II affinity purified antibody

Ask

View Details