QXG-6442
QXG-6442 is a CK1α Molecular Glue Degrader. QXG-6442 exhibits CK1α degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. QXG-6442 induces antiproliferative effects in MOLM-14 cell line[1].
Product Specifications
CAS Number
[3099928-67-0]
UNSPSC
12352005
Target
Casein Kinase; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.32
Smiles
O=C(C1=CN2C=CC=CC2=N1)NC3=CC4=C(C(N(C4)C5CCC(NC5=O)=O)=O)C=C3
Molecular Formula
C21H17N5O4
Molecular Weight
403.39
References & Citations
[1]Geng Q, et al. Development of Potent and Selective CK1α Molecular Glue Degraders. J Med Chem. 2025 Feb 13;68 (3) :3180-3196.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1
Available Sizes
Curated Selection
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