P2Y14 antagonist 1
P2Y14 antagonist 1 (compound 45) is a high selective and orally active P2Y14R antagonist with an IC50 of 0.70 nM. P2Y14R antagonist 1 demonstrates significant anti-inflammatory efficacy, effectively mitigating the pulmonary infiltration of immune cells and inflammatory response through suppressing the NLRP3 signaling pathway. P2Y14R antagonist 1 has the potential for the research of acute lung injury[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; P2Y Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=CC(C2=NC3=C(N2)C=CC=C3)=CC(C(OC)=O)=C1)CC4=CC=C(C=C4)C
Molecular Formula
C24H21N3O3
Molecular Weight
399.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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