STING-IN-11
STING-IN-11 (Compound 42) is an orally active STING inhibitor with an IC50 of 37.8 nM. STING-IN-11 can block the palmitoylation of the STING protein and STING downstream signaling, and inhibit STING-mediated inflammation. STING-IN-11 has good in vivo safety and can be used for the research of STING-related inflammatory and autoimmune diseases[1].
Product Specifications
CAS Number
[2925028-15-3]
UNSPSC
12352005
Target
Interleukin Related; STING
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Purity
98.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CNC2=C1C=C(Cl)C=C2)NC3=CC=C(C4CCC(F)(CC4)F)C=C3
Molecular Formula
C21H20ClF2N3O
Molecular Weight
403.85
References & Citations
[1]Han X, et al. Discovery of an Orally Bioavailable STING Inhibitor with In Vivo Anti-Inflammatory Activity in Mice with STING-Mediated Inflammation. J Med Chem. 2025 Feb 13;68 (3) :2963-2980.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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