STING-IN-11

STING-IN-11 (Compound 42) is an orally active STING inhibitor with an IC50 of 37.8 nM. STING-IN-11 can block the palmitoylation of the STING protein and STING downstream signaling, and inhibit STING-mediated inflammation. STING-IN-11 has good in vivo safety and can be used for the research of STING-related inflammatory and autoimmune diseases[1].

Product Specifications

CAS Number

[2925028-15-3]

UNSPSC

12352005

Target

Interleukin Related; STING

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Purity

98.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CNC2=C1C=C(Cl)C=C2)NC3=CC=C(C4CCC(F)(CC4)F)C=C3

Molecular Formula

C21H20ClF2N3O

Molecular Weight

403.85

References & Citations

[1]Han X, et al. Discovery of an Orally Bioavailable STING Inhibitor with In Vivo Anti-Inflammatory Activity in Mice with STING-Mediated Inflammation. J Med Chem. 2025 Feb 13;68 (3) :2963-2980.