Antidepressant agent 9
Antidepressant agent 9 (Compound 24) is an orally active and BBB-penetrable NMDAR and SERT inhibitor with IC50 values of 3.50 μM and 1044 nM, respectively. Antidepressant agent 9 has good metabolic stability and plasma exposure. Antidepressant agent 9 can exert antidepressant-like activity in the mouse forced swim test[1].
Product Specifications
CAS Number
143899-90-5
UNSPSC
12352005
Target
IGluR; Serotonin Transporter
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CN1[C@]2([H])[C@]3([H])[C@@](CC1)(CCCC3)C4=CC(N)=CC=C4C2
Molecular Formula
C17H24N2
Molecular Weight
256.39
References & Citations
[1]Ji J, et al. D-morphinan analogs with favorable pharmacokinetic profiles as dual-acting antidepressants. Eur J Med Chem. 2025 Apr 5;287:117349.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Sinorhizobium medicae Bifunctional protein GlmU (glmU)
Recombinant Sinorhizobium medicae Bifunctional protein GlmU (glmU)
Recombinant Sinorhizobium medicae Bifunctional protein GlmU (glmU)
Recombinant Sinorhizobium medicae Bifunctional protein GlmU (glmU)
Recombinant Sinorhizobium medicae Bifunctional protein GlmU (glmU)