Antidepressant agent 9
Antidepressant agent 9 (Compound 24) is an orally active and BBB-penetrable NMDAR and SERT inhibitor with IC50 values of 3.50 μM and 1044 nM, respectively. Antidepressant agent 9 has good metabolic stability and plasma exposure. Antidepressant agent 9 can exert antidepressant-like activity in the mouse forced swim test[1].
Product Specifications
CAS Number
[143899-90-5]
UNSPSC
12352005
Target
IGluR; Serotonin Transporter
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CN1[C@]2([H])[C@]3([H])[C@@](CC1)(CCCC3)C4=CC(N)=CC=C4C2
Molecular Formula
C17H24N2
Molecular Weight
256.39
References & Citations
[1]Ji J, et al. D-morphinan analogs with favorable pharmacokinetic profiles as dual-acting antidepressants. Eur J Med Chem. 2025 Apr 5;287:117349.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Burkholderia pseudomallei UPF0289 protein BURPS668_3510 (BURPS668_3510)
