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CDK9/PARP-IN-1

CDK9/PARP-IN-1 (compound 37) is a CDK9/PARP inhibitor. CDK9/PARP-IN-1 inhibits CDK9 and PARP1 with IC50s of 118 and 107 nM, respectively. CDK9/PARP-IN-1 exhibits broad-spectrum antiproliferative effects across multiple cancer cell lines[1].

Product Specifications

CAS Number

3032818-67-7

UNSPSC

12352005

Target

CDK; PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(CC4=CC(NC5=NC=NC(C6=CC=C(F)C=C6OCC)=C5)=NC=C4)CC3)=O)=C2)C7=C1C=CC=C7

Molecular Formula

C38H34F2N8O3

Molecular Weight

688.73

References & Citations

[1]Huang J, et al. Design, synthesis and biological evaluation of dual CDK9/PARP inhibitors for the treatment of cancer. Eur J Med Chem. 2025 Apr 5;287:117367.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK9; PARP1

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