Urease-IN-20
Urease-IN-20 (compound XBP2) is an inhibitor of Helicobacter pylori (H. pylori) . Urease-IN-20 inhibits H. pylori with an IC50 of 0.14 μM. Urease-IN-20 reduces cell Apoptosis and decreases ROS and γH2AX in GES-1 cells infected with H. pylori. Urease-IN-20 exhibits significant gastric mucosal protective effects. Urease-IN-20 shows the potential for H. pylori research[1].
Product Specifications
CAS Number
2998940-98-8
UNSPSC
12352005
Target
Apoptosis; Bacterial; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=C(C1=CC=CC(F)=C1)OC2=N[Se]C3=CC=CC=C32
Molecular Formula
C14H8FNO2Se
Molecular Weight
320.18
References & Citations
[1]Cao W, et al. Synthesis and evaluation of novel ebselen derivatives as urease inhibitors for combating Helicobacter pylori infections. Eur J Med Chem. 2025 Apr 5;287:117359.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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