MY-1576
MY-1576 is a FAK inhibitor with an IC50 of 8 nM. MY-1576 can activate the Hippo pathway, thereby blocking the regulation of YAP/TAZ. MY-1576 also effectively inhibits tumor growth in the KYSE30 xenograft mouse model, demonstrating good safety, and effectively downregulates the autophosphorylation of FAK and the levels of YAP/TAZ in vivo[1].
Product Specifications
UNSPSC
12352005
Target
FAK; Hippo (MST) ; YAP
Related Pathways
Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
ClC(C(NC1=CC=CC=C1C(NC)=O)=N2)=CN=C2NC(C=C3)=CC=C3NC(N4CCN(CC4)CC)=O
Molecular Formula
C25H29ClN8O2
Molecular Weight
509.00
References & Citations
[1]Wang X, et al. Discovery of 2,4-diaminopyrimidine derivatives as potent inhibitors of FAK capable of activating the Hippo pathway for the treatment of esophageal squamous cell carcinoma. Eur J Med Chem. 2025 Apr 5;287:117328.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YAP/TAZ
Frequently Asked Questions
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