MY-1576

MY-1576 is a FAK inhibitor with an IC50 of 8 nM. MY-1576 can activate the Hippo pathway, thereby blocking the regulation of YAP/TAZ. MY-1576 also effectively inhibits tumor growth in the KYSE30 xenograft mouse model, demonstrating good safety, and effectively downregulates the autophosphorylation of FAK and the levels of YAP/TAZ in vivo[1].

Product Specifications

UNSPSC

12352005

Target

FAK; Hippo (MST) ; YAP

Related Pathways

Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

ClC(C(NC1=CC=CC=C1C(NC)=O)=N2)=CN=C2NC(C=C3)=CC=C3NC(N4CCN(CC4)CC)=O

Molecular Formula

C25H29ClN8O2

Molecular Weight

509.00

References & Citations

[1]Wang X, et al. Discovery of 2,4-diaminopyrimidine derivatives as potent inhibitors of FAK capable of activating the Hippo pathway for the treatment of esophageal squamous cell carcinoma. Eur J Med Chem. 2025 Apr 5;287:117328.