EGFR/COX-2-IN-1

EGFR/COX-2-IN-1 is an EGFR/COX-2 inhibitor. EGFR/COX-2-IN-1 inhibits EGFRWT, EGFRT790M, COX-1 and COX-2 with IC50s of 0.12, 0.076, 20.1 and 1.52 μM respectively. EGFR/COX-2-IN-1 inhibits and with IC50s of , respectively. EGFR/COX-2-IN-1 inhibits MCF-7, HT-29 and A-549 with IC50s of 1.20, 5.14 and 14.81 μM, respectively. EGFR/COX-2-IN-1 displays Apoptosis induction by up-regulating Bax and down-regulating Bcl-2 protein levels. EGFR/COX-2-IN-1 results in a significant increase in the percentage of cells at the G2/M in MFC-7 cells. EGFR/COX-2-IN-1 exhibits broad-spectrum antitumor effects[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; COX; EGFR

Related Pathways

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

SC1=NN=C(C2=C(C)N(C3=CC=C(S(=O)(C)=O)C=C3)N=C2)N1/N=C/C4=CC=C(F)C=C4

Molecular Formula

C20H17FN6O2S2

Molecular Weight

456.52

References & Citations

[1]Kahk NM, et al. Optimization of pyrazole/1,2,4-triazole as dual EGFR/COX-2 inhibitors: Design, synthesis, anticancer potential, apoptosis induction and cell cycle analysis. Eur J Med Chem. 2025 Apr 5;287:117340.