AMPK activator 16

AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells[1].

Product Specifications

CAS Number

[2252336-04-0]

UNSPSC

12352005

Target

Acetyl-CoA Carboxylase; AMPK

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Smiles

O=S(C1=CC=C(Cl)C=C1)(NC2=CC=C(C(/C=C/C3=CC(OC)=CC=C3OC)=O)C=C2)=O

Molecular Formula

C23H20ClNO5S

Molecular Weight

457.93

References & Citations

[1]Jeon KH, et al. Computer-aided discovery of novel AMPK activators through virtual screening and SAR-driven synthesis. Eur J Med Chem. 2025 Apr 5;287:117318.