Anticonvulsant agent 9

Anticonvulsant agent 9 (compound 4f) is an α1β2γ2 GABAA receptors activator. Anticonvulsant agent 9 activatesα1β2γ2 GABAA receptors with an EC50 of 1.24 μM. Anticonvulsant agent 9 inhibits the inactivation of Nav1.2 channels. Anticonvulsant agent 9 exhibits significant anticonvulsant activities[1].

Product Specifications

UNSPSC

12352005

Target

GABA Receptor; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

COC1=CC=C(C2=NN3C(N(CCCC)C(CC3C4=CC=CC=C4)=O)=N2)C=C1

Molecular Formula

C22H24N4O2

Molecular Weight

376.45

References & Citations

[1]Du T, et al. Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABAA1 and Nav1.2 with antiepileptic activity. Eur J Med Chem. 2025 Mar 15;286:117316.