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EMT inhibitor-3

EMT inhibitor-3 (compound 11i) is a epithelial-mesenchymal transition (EMT) inhibitor. EMT inhibitor-3 inhibits neuroblastoma SK-N-SH cells with an IC50 of 2.5 μM. EMT inhibitor-3 inhibits SK-N-SH cell proliferation, migration, and invasion. EMT inhibitor-3 increases the Bax/Bcl-2 protein expression ratio, promotes Cytochrome C release from mitochondria, and activates caspases 9 and caspases 3, inducing mitochondria-mediated endogenous tumor cell Apoptosis. EMT inhibitor-3 is potential for cancer research[1].

Product Specifications

CAS Number

2930726-89-7

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; Cytochrome P450

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1C(C(N2N=C(C3=CC=C(F)C=C3)CC2C4=CC=C(F)C=C4)=O)=CC5=C(O1)C=C(OCCC[Se]C#N)C=C5

Molecular Formula

C29H21F2N3O4Se

Molecular Weight

592.45

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Bax; Bcl-2; Caspase 3; Caspase 9

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