JAK-IN-40

JAK-IN-40 (Compound 46) is the inhibitor for JAK that inhibits JAK1, JAK2 and JAK3 with IC50s of 0.022, 0.759 and 1.601 μM, respectively. JAK-IN-40 inhibits the phosphorylation of STAT3. JAK-IN-40 inhibits the proliferation of cancer cell Ba/F3 and JAK1-TEL Ba/F3 with GI50 of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle of H1975 and H2087 at G2/M phase, induces apoptosis. JAK-IN-40 exhibits a synergistic antitumor effect with Osimertinib (HY-15772) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; JAK; STAT

Related Pathways

Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(NC1=CC=CC(C2=CSC3=CN=C(NC4=CN(C)N=C4OC)N=C32)=C1)[C@@H](C)N5CCN(CCO)CC5

Molecular Formula

C26H32N8O3S

Molecular Weight

536.65

References & Citations

[1]Kim Y, et al., Identification of Thieno[3,2-d]pyrimidine derivatives as potent and selective Janus Kinase 1 inhibitors. Eur J Med Chem. 2025 Mar 15;286:117308.