AChE-IN-81
AChE-IN-81 (compound 22) is a potent, irreversible and selective AChE inhibitor. AChE-IN-81 inhibits activity on AChE with inhibitory rates of 80.0%, with an IC50 of 3.7 μM. AChE-IN-81 binds to AChE with a binding affinity (Kd) of 5.37 μM. AChE-IN-81 effectively reduces in zebrafish brain cells. AChE-IN-81 exhibits potential neuroprotective activities on H2O2-induced SH-SY5Y cell injury model[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Cholinesterase (ChE)
Related Pathways
Apoptosis; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
ClC1=CC=CC=C1CNC([C@@]23CC[C@@]4(C)[C@]5(C)CC[C@@]6([H])[C@@](CO)(C)[C@@H](O)[C@H](O)C[C@]6(C)[C@@]5([H])CC=C4[C@@]([H])2[C@](C)(O)[C@H](C)CC3)=O
Molecular Formula
C37H54ClNO5
Molecular Weight
628.28
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
Frequently Asked Questions
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