USP1-IN-11
USP1-IN-11 (compound 38-P2) is a selective, reversible, and noncompetitive USP1 (Ubiquitin-specific protease 1) inhibitor. USP1-IN-11 activates the DDR (DNA damage repair) pathway, induces cell cycle arrest and cell Apoptosis, and inhibits cell survival. USP1-IN-11 enhances the sensitivity of Olaparib (HY-10162) -resistant cells to Olaparib (HY-10162) and shows a synergetic effect with Andrographolide (HY-N0191) in BRCA-proficient cancer cells. USP1-IN-11 displays significant, dose-dependent antitumor efficacy in the MDA-MB-436 xenograft model[1].
Product Specifications
UNSPSC
12352005
Target
Deubiquitinase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CC(C)N1C(C2=CC=C(C=C2)[C@@H]3COCCN3C4=C5C(C=CO5)=NC(C6=C(N=CN=C6OC)C7CC7)=N4)=NC(C(F)(F)F)=C1
Molecular Formula
C31H30F3N7O3
Molecular Weight
605.61
References & Citations
[1]Zhang J, et al. Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors. J Med Chem. 2025 Feb 13;68 (3) :3673-3699.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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