BKCa activator-1
BKCa activator-1 (Compound 51b) is the orally active activator for the calcium-activated potassium channel BKCa with an EC50 of 2.82 μM. BKCa activator-1 increases K+ efflux, leads to cell membrane hyperpolarization, thereby inhibiting smooth muscle contraction. BKCa activator-1 alleviates urinary incontinence in spontaneously hypertensive rat (SHR) model, exhibits antitussive effect in puinea pig cough model[1].
Product Specifications
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Smiles
OC1=C(C=CC(NCCCCCN2CCOCC2)=C1)OC3=C(C(F)=C(C(F)=C3F)C(F)(F)F)F
Molecular Formula
C22H23F7N2O3
Molecular Weight
496.42
References & Citations
[1]Park SB, et al., Discovery of Diphenyl Ether Derivatives as Novel BKCa Channel Activators: Structure-Activity Relationship, Cryo-EM Complex Structures, and In Vivo Animal Studies. J Med Chem. 2025 Feb 27;68 (4) :4259-4286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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