PHD2-IN-4
PHD2-IN-4 (compound 1) is a PHD2 inhibitor. PHD2-IN-4 inhibits PHD2 with an IC50 of 4 nM. PHD2-IN-4 is potential for chronic kidney disease research[1].
Product Specifications
CAS Number
[2924181-60-0]
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolic Enzyme/Protease
Smiles
O=C(C1=C(O)C2=C(C=N1)N=C(C=C2)N3CCOCC3)NCC4=CC=C(C#N)C=C4
Molecular Formula
C21H19N5O3
Molecular Weight
389.41
References & Citations
[1]Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 25;67 (2) :1393-1405.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIF-1α
Curated Selection
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