Topo I/II-IN-2
Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC50s of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer) cell proliferation, invasion, and migration in vitro. [1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; Bcl-2 Family; Caspase; Cytochrome P450; mTOR; PI3K; ROS Kinase; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC(C1)CC(C)CN1CC2=CC(OCO3)=C3C=C2C4=CC(C=CC5=C6OCO5)=C6C=N4
Molecular Formula
C25H26N2O4
Molecular Weight
418.48
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; Caspase 9; Topo I; Topo II
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