HDAC-IN-85

HDAC-IN-85 (Compound 1) is a BBB-permeable HDAC inhibitor. HDAC-IN-85 has an inhibitory effect on brain tumor cell lines. HDAC-IN-85 can induce acetylation, leading to DNA double-strand breaks, and induce the ubiquitination of RAD51, disrupting the DNA repair process. HDAC-IN-85 can be used in the research of glioblastoma[1].

Product Specifications

UNSPSC

12352005

Target

DNA/RNA Synthesis; HDAC; RAD51

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(NO)/C=C/C1=CC=C(CNC[C@H]2CN(C3=CC=C(N4CCOCC4)C(F)=C3)C(O2)=O)C=C1

Molecular Formula

C24H27FN4O5

Molecular Weight

470.49

References & Citations

[1]Chen IC, et al. Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies. J Med Chem. 2025 Feb 13;68 (3) :2779-2803.