HDAC-IN-85
HDAC-IN-85 (Compound 1) is a BBB-permeable HDAC inhibitor. HDAC-IN-85 has an inhibitory effect on brain tumor cell lines. HDAC-IN-85 can induce acetylation, leading to DNA double-strand breaks, and induce the ubiquitination of RAD51, disrupting the DNA repair process. HDAC-IN-85 can be used in the research of glioblastoma[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis; HDAC; RAD51
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C(NO)/C=C/C1=CC=C(CNC[C@H]2CN(C3=CC=C(N4CCOCC4)C(F)=C3)C(O2)=O)C=C1
Molecular Formula
C24H27FN4O5
Molecular Weight
470.49
References & Citations
[1]Chen IC, et al. Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies. J Med Chem. 2025 Feb 13;68 (3) :2779-2803.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-170907/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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