HDAC-IN-85
HDAC-IN-85 (Compound 1) is a BBB-permeable HDAC inhibitor. HDAC-IN-85 has an inhibitory effect on brain tumor cell lines. HDAC-IN-85 can induce acetylation, leading to DNA double-strand breaks, and induce the ubiquitination of RAD51, disrupting the DNA repair process. HDAC-IN-85 can be used in the research of glioblastoma[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis; HDAC; RAD51
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C(NO)/C=C/C1=CC=C(CNC[C@H]2CN(C3=CC=C(N4CCOCC4)C(F)=C3)C(O2)=O)C=C1
Molecular Formula
C24H27FN4O5
Molecular Weight
470.49
References & Citations
[1]Chen IC, et al. Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies. J Med Chem. 2025 Feb 13;68 (3) :2779-2803.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
abx145099-01 100 µg
E3 Ubiquitin-Protein Ligase Parkin (PRKN) Antibody
Sign In for Pricing
View Details abx145099-02 1 mg
E3 Ubiquitin-Protein Ligase Parkin (PRKN) Antibody
Sign In for Pricing
View Details 
MBS9380771 Inquire
Plant Cytosolic Phospholipase A2 (CPLA2) ELISA Kit
Sign In for Pricing
View Details 
MBS7141636 Inquire
Rabbit anti-Caenorhabditis elegans H14A12.3 Polyclonal Antibody
Sign In for Pricing
View Details