MAT2A-IN-22
MAT2A-IN-22 (Compound 29-1) is a BBB-penetrable and orally active MAT2A inhibitor with an IC50 of 4 nM. MAT2A-IN-22 shows selectivity and inhibitory activity against MTAP-deficient cancer cell lines. MAT2A-IN-22 has anti-tumor effects[1].
Product Specifications
CAS Number
2925330-18-1
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Methionine Adenosyltransferase (MAT)
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1[C@]2(C3=CC(C(F)(F)F)=CC=C3C(NC([2H])([2H])[2H])=N1)C4=CC=CN=C4CC2
Molecular Formula
C18H11D3F3N3O
Molecular Weight
348.34
References & Citations
[1]Yang S, et al. Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models. J Med Chem. 2025 Feb 13;68 (3) :3480-3494.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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