TLR7 agonist 28
TLR7 agonist 28 (compound 3) is a potent TLR7 agonist. TLR7 agonist 28 can conjugat to antitumor monoclonal antibodies (mAbs) for cancer immunotherapy[1].
Product Specifications
CAS Number
[1801518-98-8]
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C(N(C1=NC(OCCOC)=N2)CC3=CC=C(C=C3)/C=N/NC4=CC=C(C=N4)C(ON5C(CCC5=O)=O)=O)NC1=C2N
Molecular Formula
C26H25N9O7
Molecular Weight
575.53
References & Citations
[1]Gadd AJ, et al. Targeted Activation of Toll-Like Receptors: Conjugation of a Toll-Like Receptor 7 Agonist to a Monoclonal Antibody Maintains Antigen Binding and Specificity. Bioconjug Chem. 2015 Aug 19;26 (8) :1743-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7
Curated Selection
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