Antidepressant agent 8

Antidepressant agent 8 (Compound 1f) is a selective antagonist for the NMDA receptor GluN1/2A with an IC50 of 2.94 μmol/L. Antidepressant agent 8 exhibits antidepressant-like effects in Hydrocortisone (HY-N0583) -induced zebrafish depression model. Antidepressant agent 8 can cross blood-brain barrier[1].

Product Specifications

CAS Number

[3066104-04-6]

UNSPSC

12352005

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

FC1=CC(CNC2=NN=C(SCC(NCC3CCCCC3)=O)S2)=CC=C1

Molecular Formula

C18H23FN4OS2

Molecular Weight

394.53

References & Citations

[1]Zhao F, et al., Discovery of Brain-Penetrative Negative Allosteric Modulators of NMDA Receptors Using FEP-Guided Structure Optimization and Membrane Permeability Prediction. J Chem Inf Model. 2025 Jan 27;65 (2) :857-872.