Hsp90-IN-38

Hsp90-IN-38 (compound 20m) is a HSP90 (heat shock protein) inhibitor. Hsp90-IN-38 exhibits strong HSP90 binding affinity with a Kd of 87 nM. Hsp90-IN-38 inhibits ATPase with an IC50 of 0.13 μM. Hsp90-IN-38 inhibits HCT116, MCF-7, SKBr3, K562 and A549 cells with IC50s of 0.187, 0.072, 0.105, 0.403 and 031 μM, respectively[1].

Product Specifications

CAS Number

[3065556-04-6]

UNSPSC

12352005

Target

HSP; Na+/K+ ATPase

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C([C@@H]1N(C(C2=CC(C3CC3)=C(O)C=C2O)=O)C[C@@H](C4=CC=CC=C4)C1)NCCCN5CCOCC5

Molecular Formula

C28H35N3O5

Molecular Weight

493.59

References & Citations

[1]Zhang C, et al. Design, Synthesis, and Biological Evaluation of Chiral-Proline Derivatives as Novel HSP90 Inhibitors. ACS Med Chem Lett. 2025 Jan 22;16 (2) :301-310.