Hsp90-IN-38
Hsp90-IN-38 (compound 20m) is a HSP90 (heat shock protein) inhibitor. Hsp90-IN-38 exhibits strong HSP90 binding affinity with a Kd of 87 nM. Hsp90-IN-38 inhibits ATPase with an IC50 of 0.13 μM. Hsp90-IN-38 inhibits HCT116, MCF-7, SKBr3, K562 and A549 cells with IC50s of 0.187, 0.072, 0.105, 0.403 and 031 μM, respectively[1].
Product Specifications
CAS Number
[3065556-04-6]
UNSPSC
12352005
Target
HSP; Na+/K+ ATPase
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C([C@@H]1N(C(C2=CC(C3CC3)=C(O)C=C2O)=O)C[C@@H](C4=CC=CC=C4)C1)NCCCN5CCOCC5
Molecular Formula
C28H35N3O5
Molecular Weight
493.59
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-170895/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
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