SARS-CoV-2 Mpro-IN-37

SARS-CoV-2 Mpro-IN-37 (compound 8r) is a SARS-CoV-2 main protease (Mpro) inhibitor, with an IC50 of 0.0199 μM. SARS-CoV-2 Mpro-IN-37 inhibits SARS-CoV-1 Mpro and MERS-CoV Mpro with IC50s of 0.00945 and 0.111 μM, respectively. SARS-CoV-2 Mpro-IN-37 displays high antiviral activity in the nanomolar range without showing cellular toxicity[1].

Product Specifications

UNSPSC

12352005

Target

SARS-CoV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CC(C)C[C@H](NC(CSC1=CC=CC=C1)=O)C(N[C@H](C(C=C)=O)CC2=CC=CC=C2)=O

Molecular Formula

C25H30N2O3S

Molecular Weight

438.58

References & Citations

[1]Flury P, et al. Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity. J Med Chem. 2025 Feb 13;68 (3) :3626-3652.