CAIX/CAXII-IN-4
CAIX/CAXII-IN-4 (Compound 7h) is the inhibitor for carbonic anhydrase (CA) that binds CA IX, CA XII and CA II with Ki of 1.324 μM, 0.435 μM and 3.035 μM. CAIX/CAXII-IN-4 exhibits board-spectrum antitumor efficacy, inhibits the proliferation of CNS cancer U251 with GI50 of 0.361 μM[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC1=CC(C)=CC(C(NC2=CC=CC(C3=CN(C4=CC=C(S(=O)(N)=O)C=C4)N=N3)=C2)=O)=C1
Molecular Formula
C23H21N5O3S
Molecular Weight
447.51
References & Citations
[1]El-Damasy AK, et al., Novel N- (3- (1- (4-sulfamoylphenyl) triazol-4-yl) phenyl) benzamide Derivatives as Potent Carbonic Anhydrase Inhibitors with Broad-Spectrum Anticancer Activity: Leveraging Tail and Dual-Tail Approaches. J Med Chem. 2025 Feb 13;68 (3) :3764-3781.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA IX; CA XII
Curated Selection
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