Type-I/-II Photosensitizer-1

Type-I/-II Photosensitizer-1 (compound 8b) is a photosensitizer with anticancer activity. Type-I/-II Photosensitizer-1 exhibits significant phototoxicity against both A549 and 4T1 tumor cells. Type-I/-II Photosensitizer-1 shows a strong oxygen-independent antitumor effect under laser irradiation (IC50=1.50-1.76 μM) [1].

Product Specifications

UNSPSC

12352005

Target

Photosensitizer

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

FP(F)(F)(F)(F)F.FP(F)(F)(F)(F)F.C1(C2=CC=C(C=CC=C3)C3=[N]2[Ru+2]45[N]6=CC=CC7=C6C([N]5=CC=C8)=C8C(CN9CCN(CC%10=CC=CC=C%10)CC9)=C7)=[N]4C(C=CC=C%11)=C%11C=C1.[2]

Molecular Formula

C60H48N8Ru.2F6P

Molecular Weight

1272.07

References & Citations

[1]Liu X, et al. Novel Ru (II) Complexes as Type-I/-II Photosensitizers for Multimodal Hypoxia-Tolerant Chemo-Photodynamic/Immune Therapy. Mol Pharm. 2025 Feb 3;22 (2) :882-894.