TIR-199

TIR-199 is a novel and highly specific dual proteasome inhibitor that can effectively inhibit the PSMB5 subunit of constitutive proteasome and the PSMB8 subunit of immunoproteasome. TIR-199 can induce the death of various tumor cells. TIR-199 can be used for research on myeloma[1].

Product Specifications

CAS Number

[1514925-83-7]

UNSPSC

12352005

Target

Proteasome

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CC(C)[C@H](NC(NCCCCCCCCCCCC)=O)C(N[C@@H]1C(N[C@@H](C)/C=C/C(NCC/C=C/1)=O)=O)=O

Molecular Formula

C29H51N5O4

Molecular Weight

533.75

References & Citations

[1]Tandon V, et al. Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo. Biosci Rep. 2022 Feb 25;42 (2) :BSR20212721.