SHP2-IN-35
SHP2-IN-35 (Compound 3f) is the inhibitor for SHP2. SHP2-IN-35 exhibits antiproliferative activity in cancer cells RKO, SW480 and CT26 with IC50 of 5.72 μM, 3.71 μM and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the cell cycle associated gene expressions, and induces mitochondrial-related autophagy. SHP2-IN-35 inhibits the expression of certain cytokines and chemokines in the tumor microenvironment (TME), thereby regulating the tumor progression[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Autophagy; PI3K; SHP2
Related Pathways
Autophagy; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(/C=C/C1=CC=C(OC)C(OC)=C1)/C(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)=C/c3cccc3.[][Fe][].c4cccc4
Molecular Formula
C34H32FeO6
Molecular Weight
592.46
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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