PPARγ modulator-2

PPARγ modulator-2 (Compound (R) -2n) is the reversible modulator for PPARγ that inhibits PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. PPARγ modulator-2 reduces blood glucose, improves the glucose tolerance and insulin tolerance, and exhibits anti-diabetic efficacy in db/db mouse models[1].

Product Specifications

CAS Number

[2897652-01-4]

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease

Smiles

O=S1(C2=CC=C(C=C2)OS(C3=CC=C(C=C3)C)(=O)=O)=N[Se]C4=CC(OS(C5=CC=C(C=C5)C)(=O)=O)=CC=C41

Molecular Formula

C26H21NO7S3Se

Molecular Weight

634.60

References & Citations

[1]Chen F, et al., Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery. J Med Chem. 2025 Jan 9;68 (1) :819-831.