PPARγ modulator-2
PPARγ modulator-2 (Compound (R) -2n) is the reversible modulator for PPARγ that inhibits PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. PPARγ modulator-2 reduces blood glucose, improves the glucose tolerance and insulin tolerance, and exhibits anti-diabetic efficacy in db/db mouse models[1].
Product Specifications
CAS Number
2897652-01-4
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O=S1(C2=CC=C(C=C2)OS(C3=CC=C(C=C3)C)(=O)=O)=N[Se]C4=CC(OS(C5=CC=C(C=C5)C)(=O)=O)=CC=C41
Molecular Formula
C26H21NO7S3Se
Molecular Weight
634.60
References & Citations
[1]Chen F, et al., Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery. J Med Chem. 2025 Jan 9;68 (1) :819-831.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ
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