Nrf2/HO-1 activator 3

Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H2O2- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy[1].

Product Specifications

UNSPSC

12352005

Target

Heme Oxygenase (HO) ; Keap1-Nrf2; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cardiovascular Disease

Smiles

O=C1NC2=C(C=CC=C2)C13N(C)C[C@H](C4=C(OC)C=CC=C4OC)[C@@H]3C(C5=CC=C(O)C(O)=C5)=O

Molecular Formula

C27H26N2O6

Molecular Weight

474.51

References & Citations

[1]Zheng Z, et al. Design and synthesis of novel antioxidants derived from chalcones and their protective effects on cardiomyocytes by activating Nrf2/HO-1 pathway[J]. Bioorganic & Medicinal Chemistry Letters, 2025, 118: 130086.