Nrf2/HO-1 activator 3
Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H2O2- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy[1].
Product Specifications
UNSPSC
12352005
Target
Heme Oxygenase (HO) ; Keap1-Nrf2; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cardiovascular Disease
Smiles
O=C1NC2=C(C=CC=C2)C13N(C)C[C@H](C4=C(OC)C=CC=C4OC)[C@@H]3C(C5=CC=C(O)C(O)=C5)=O
Molecular Formula
C27H26N2O6
Molecular Weight
474.51
References & Citations
[1]Zheng Z, et al. Design and synthesis of novel antioxidants derived from chalcones and their protective effects on cardiomyocytes by activating Nrf2/HO-1 pathway[J]. Bioorganic & Medicinal Chemistry Letters, 2025, 118: 130086.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1143048-01 0.02 mg (E-Coli)
Recombinant Vaccinia virus Uncharacterized 8.4 kDa protein (B ORF F)
Sign In for Pricing
View Details MBS1143048-02 0.1 mg (E-Coli)
Recombinant Vaccinia virus Uncharacterized 8.4 kDa protein (B ORF F)
Sign In for Pricing
View Details MBS1143048-03 0.02 mg (Yeast)
Recombinant Vaccinia virus Uncharacterized 8.4 kDa protein (B ORF F)
Sign In for Pricing
View Details