OncoFAP-GlyPro-MMAF

OncoFAP-GlyPro-MMAF is a Drug-Linker Conjugate for ADC with potent antitumor activity. OncoFAP-GlyPro-MMAF consists of Monomethylauristatin F (HY-15579) and a linker. OncoFAP-GlyPro-MMAF can be used for synthesis of ADCs[1].

Product Specifications

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NCC(N1[C@H](C#N)CC(F)(F)C1)=O)C2=CC=NC3=C(NC(CCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CSC4C(N(CCCCCC(NCC(N5[C@H](C(NC6=CC=C(COC(N([C@@H](C(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N7CCC[C@H]7[C@H](OC)[C@@H](C)C(N[C@H](C(O)=O)CC8=CC=CC=C8)=O)=O)OC)C)=O)C(C)C)=O)C)=O)C=C6)=O)CCC5)=O)=O)C(C4)=O)=O)=O)=O)=O)=O)=O)C=CC=C32

Molecular Formula

C102H139F2N19O28S

Molecular Weight

2149.37

References & Citations

[1]Bocci M, et al. Delivery of Monomethyl Auristatin F to the Tumor Microenvironment with Noninternalizing Fibroblast Activation Protein-Cleavable Small Molecule-Drug Conjugates Elicits Potent In Vivo Anticancer Activity. Bioconjug Chem. 2025 Jan 15;36 (1) :15-19.