AH081
AH081 (Compound 38) is a CK1δ/ε PROTAC degrader. AH081 is the negative control compound of AH078. AH081 has inhibitory but no degradation activity for CK1δ/ε by using an inactive stereoisomer of the VHL ligand[1]. Pink: CK1δ/ε ligand (HY-148251) ; Blue: VHL ligase ligand (HY-125845B) ; Black: linker
Product Specifications
UNSPSC
12352005
Target
Casein Kinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCCC(N4CCC(F)(CC4)CN5C(C6=C7C(NC=C7)=NC=C6)=C(N=C5)C8=NC=C(C=C8)F)=O)=O)=O
Molecular Formula
C51H60F2N10O5S
Molecular Weight
963.15
References & Citations
[1]Haag A, et al. Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε. J Med Chem. 2025 Jan 9;68 (1) :506-530.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Rat Tnfrsf1a (Tumor necrosis factor receptor superfamily member 1A) ELISA Kit
CXCL11 Polyclonal Antibody, AbBy Fluor™ 594 Conjugated
KRT8P24 sgRNA CRISPR Lentivector (Human) (Target 2)