AH081
AH081 (Compound 38) is a CK1δ/ε PROTAC degrader. AH081 is the negative control compound of AH078 (HY-170859) . AH081 has inhibitory but no degradation activity for CK1δ/ε by using an inactive stereoisomer of the VHL ligand[1]. Pink: CK1δ/ε ligand (HY-148251) ; Blue: VHL ligase ligand (HY-125845B) ; Black: linker
Product Specifications
UNSPSC
12352005
Target
Casein Kinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCCC(N4CCC(F)(CC4)CN5C(C6=C7C(NC=C7)=NC=C6)=C(N=C5)C8=NC=C(C=C8)F)=O)=O)=O
Molecular Formula
C51H60F2N10O5S
Molecular Weight
963.15
References & Citations
[1]Haag A, et al. Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε. J Med Chem. 2025 Jan 9;68 (1) :506-530.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1
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