E3 Ligase Ligand-linker Conjugate 162

E3 Ligase Ligand-linker Conjugate 162 is an E3 ligase ligand-linker conjugate of YW-N-7 (TFA) (HY-170855A) . YW-N-7 (TFA) is a PROTAC that targets the degradation of RET kinase and can be used in cancer research applications [1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(NCCOC1=CC=C(C(CC2)C(NC2=O)=O)C=C1)C3=CN=C(N4CCN(C(OC(C)(C)C)=O)CC4)C=C3

Molecular Formula

C28H35N5O6

Molecular Weight

537.61

References & Citations

[1]Wang Y, et al. Targeting Oncogenic RET Kinase by Simultaneously Inhibiting Kinase Activity and Degrading the Protein. J Med Chem. 2025 Jan 9;68 (1) :81-94.