YW-N-7 (TFA)

YW-N-7 (TFA) is a PROTAC that targets both the inhibition and degradation of RET kinase, with a DC50 of 88 nM. YW-N-7 (TFA) exhibits antitumor activity in a KIF5B-RET-driven xenograft mouse tumor model and can be used in the area of cancer (Structure: red part represents the target protein ligand: HY-170856; blue part represents the E3 ligase ligand: HY-1708557; black part represents the linker; E3 ligase ligand + linker: HY-170858) [1].

Product Specifications

UNSPSC

12352005

Target

PROTACs; RET

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(C1=CN=C(C=C1)N2CCN(CC2)C(CCCCCCCOC3=CN4C(C(C5=CC=C(N=C5)N6CC7CC(C6)N7CC8=CC=C(N=C8)OC)=C3)=C(C=N4)C#N)=O)NCCOC9=CC=C(C=C9)C(C(N%10)=O)CCC%10=O.O=C(O)C(F)(F)F

Molecular Formula

C58H63F3N12O9

Molecular Weight

1129.19

References & Citations

[1]Wang Y, et al. Targeting Oncogenic RET Kinase by Simultaneously Inhibiting Kinase Activity and Degrading the Protein. J Med Chem. 2025 Jan 9;68 (1) :81-94.