RET ligand-3
RET ligand-3 is the ligand for targeting RET PROTAC QZ2135 (HY-170852) [1].
Product Specifications
UNSPSC
12352005
Target
PROTACs; RET
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Smiles
N#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(C7=CN(C8CCN(C(OC(C)(C)C)=O)CC8)N=C7)=CN2N=C1
Molecular Formula
C38H42N10O3
Molecular Weight
686.81
References & Citations
[1]Zhang Q, et al. Discovery of an Efficacious RET PROTAC Degrader with Enhanced Antiproliferative Activity against Resistant Cancer Cells Harboring RET Solvent-Front Mutations. J Med Chem. 2025 Jan 9;68 (1) :753-775.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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