MKLP2-IN-1
MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 with good oral bioavailability. MKLP2-IN-1 inhibits the microtubule-stimulated ATPase activity of recombinant MKLP2 in vitro and suppresses tumor growth in a mouse Calu-6 lung cancer model[1].
Product Specifications
CAS Number
2929345-46-8
UNSPSC
12352005
Target
Kinesin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC1=C(C)C=CC(CN2C(CC(C3=NN=C(C4CC4)O3)=C(Br)C5=CC=CC=C52)=O)=C1
Molecular Formula
C23H19BrFN3O2
Molecular Weight
468.32
References & Citations
[1]Huang J, et al. Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes[J]. European Journal of Medicinal Chemistry Reports, 2024, 11: 100145.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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