MU1409
MU1409 is an inhibitor of MRE11 nuclease with an IC50 of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC50 values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers[1].
Product Specifications
CAS Number
[2379671-78-8]
UNSPSC
12352005
Target
Endonuclease
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
98.52
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC(/C=C(C#N)/C(NC2=NC(CC3=CC=CC=C3)=CS2)=O)=CC(Br)=C1O
Molecular Formula
C20H14BrN3O3S
Molecular Weight
456.31
References & Citations
[1]Nikulenkov F, et al. Discovery of new inhibitors of nuclease MRE11. Eur J Med Chem. 2025 Mar 5;285:117226.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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