MU1409

MU1409 is an inhibitor of MRE11 nuclease with an IC50 of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC50 values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers[1].

Product Specifications

CAS Number

[2379671-78-8]

UNSPSC

12352005

Target

Endonuclease

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Purity

98.52

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=CC(/C=C(C#N)/C(NC2=NC(CC3=CC=CC=C3)=CS2)=O)=CC(Br)=C1O

Molecular Formula

C20H14BrN3O3S

Molecular Weight

456.31

References & Citations

[1]Nikulenkov F, et al. Discovery of new inhibitors of nuclease MRE11. Eur J Med Chem. 2025 Mar 5;285:117226.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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