MU147
MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer activity, which is lethal to Ehrlich ascites tumor cells both in vitro and in vivo. MU147 also eliminates the double-strand break repair mechanism dependent on the MRE11 nuclease activity without impairing the activation of ATM. MU147 also impairs the degradation of nascent strands of stalled replication FOX and selectively affects brca2-deficient cells[1].
Product Specifications
CAS Number
[2379405-61-3]
UNSPSC
12352005
Target
Endonuclease
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.35
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
OC1=CC(/C=C(C#N)/C(NC2=NC(C3=CC=CC=C3)=CS2)=O)=CC=C1O
Molecular Formula
C19H13N3O3S
Molecular Weight
363.39
References & Citations
[1]Nikulenkov F, et al. Discovery of new inhibitors of nuclease MRE11. Eur J Med Chem. 2025 Mar 5;285:117226.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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