Antitumor agent-198

Antitumor agent-198 (Compound A3) exhibits cytotoxicity in head and neck squamous cell carcinoma (HNSCC) cells, that inhibits the proliferation of CAL27, HN6, HN30, SCC9 and SCC25 with IC50 of 4 nM-77 nM. Antitumor agent-198 inhibits the HNSCC cell migration, arrests the cell cycle, and induces apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

O=C1OCC2=C(O[C@H]3[C@H](O)[C@@H](O)[C@]4([H])O[C@H](C5=CSC=C5)OC[C@@]4([H])O3)C6=CC(OC)=C(OC)C=C6C(C7=CC=C(OCO8)C8=C7)=C12

Molecular Formula

C32H28O12S

Molecular Weight

636.62

References & Citations

[1]Tang Y, et al., Synthesis and pharmacological evaluation of natural product diphyllin derivatives against head and neck squamous cell carcinoma. Eur J Med Chem. 2025 Mar 5;285:117215.