Antitumor agent-198
Antitumor agent-198 (Compound A3) exhibits cytotoxicity in head and neck squamous cell carcinoma (HNSCC) cells, that inhibits the proliferation of CAL27, HN6, HN30, SCC9 and SCC25 with IC50 of 4 nM-77 nM. Antitumor agent-198 inhibits the HNSCC cell migration, arrests the cell cycle, and induces apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C1OCC2=C(O[C@H]3[C@H](O)[C@@H](O)[C@]4([H])O[C@H](C5=CSC=C5)OC[C@@]4([H])O3)C6=CC(OC)=C(OC)C=C6C(C7=CC=C(OCO8)C8=C7)=C12
Molecular Formula
C32H28O12S
Molecular Weight
636.62
References & Citations
[1]Tang Y, et al., Synthesis and pharmacological evaluation of natural product diphyllin derivatives against head and neck squamous cell carcinoma. Eur J Med Chem. 2025 Mar 5;285:117215.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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