HDAC3/BRD4-IN-1
HDAC3/BRD4-IN-1 (compound 26n) is an inhibitor of HDAC3/BRD4 with an IC50 of 8 nM for HDAC3 (IC50s are 220 nM and 120 nM for HDAC1 and HDAC2, respectively) . HDAC3/BRD4-IN-1 has anti-tumor and anti-proliferative effects by upregulating Ac-H3 and downregulating c-Myc. The half-life of HDAC3/BRD4-IN-1 in human liver microsomes is 29.36 min[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=NOC(C)=C1C2=CC(CCC3=C(C(NCCCCCCC(NO)=O)=O)N(CC4=CC=CC=C4)N=C35)=C5C=C2
Molecular Formula
C31H35N5O4
Molecular Weight
541.64
References & Citations
[1]Li B, et al. Discovery of 4,5-dihydro-benzo[g]indazole-based hydroxamic acids as HDAC3/BRD4 dual inhibitors and anti-tumor agents. Eur J Med Chem. 2025 Mar 5;285:117230.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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